Transporters as Targets for Drugs

Matilda Bingham, Susan Napier (auth.), Susan Napier, Matilda Bingham (eds.)9783540879114, 3540879110

M. Bingham • S. Napier: Overview: Transporters as Targets for Drug Discovery

I. Sylte • A.W. Ravna • G. Sager • S.G. Dahl: Membrane Transporters: Structure, Function and Targets for Drug Design

G.A. Whitlock • M.D. Andrews • A.D. Brown • P.V Fish • A. Stobie • F. Wakehut: Design of Monoamine Reuptake Inhibitors – SSRIs, SNRIs and NRIs

A. Hauck Newman • J.L. Katz: Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine’s Mechanism at the Dopamine Transporter

Z. Chen • J. Yang • P. Skolnick: The Design, Synthesis and Structure-Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors

G. Antoni • J. Sörensen • H. Hall: Molecular Imaging of Transporters with Positron Emission Tomography

R. Bridges • S.A. Patel: Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System xc

R. Gilfillan • J. Kerr G. • Walker • G. Wishart: Glycine Transporters and Their Inhibitors

Table of contents :
Front Matter….Pages I-XIV
Overview: Transporters as Targets for Drug Discovery….Pages 1-13
Membrane Transporters: Structure, Function and Targets for Drug Design….Pages 15-51
Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs….Pages 53-94
Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine’s Mechanism at the Dopamine Transporter….Pages 95-129
The Design, Synthesis and Structure–Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors….Pages 131-154
Molecular Imaging of Transporters with Positron Emission Tomography….Pages 155-186
Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System x c − ….Pages 187-222
Glycine Transporters and Their Inhibitors….Pages 223-247
Back Matter….Pages 249-253