Mass Spectrometry in Drug Discovery

David T. Rossi, Michael Sinz9780824706074, 0824706072

Thirteen chapters summarize the theory, instrumentation, and application of mass spectrometry and atmospheric pressure ionization to the evaluation of drug candidates. It describes current techniques in pharmaceutics and pharmacokinetics for increased quantities of new pharmacological compounds. Chapters discuss ion chemistry and fragmentation, the LC/MS experiment, drug hydrophobicity and transport, drug metabolism, cassette dosing, microdialysis, and related subjects. Contributors include chemists at universities and researchers for drug companies. Annotation c. Book News, Inc., Portland, OR (booknews.com)