Cyclic GMP: Synthesis, Metabolism, and Function

Ferid Murad (Eds.)978-0-12-032926-7

This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed.

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Table of contents :
Content:
Advisory Board
Page ii

Edited By
Page iii

Copyright Page
Page iv

Contributors
Pages xiii-xiv

Preface
Pages xv-xvi
Ferid Murad

Introduction and Some Historical Comments Original Research Article
Pages 1-5
Ferid Murad

Cloning of Guonylyl Cyclase Isoforms Original Research Article
Pages 7-18
Masaki Nakane, Ferid Murad

Regulation of Cytosolic Guanylyl Cyclase by Nitric Oxide: The NO-Cyclic GMP Signal Transduction System Original Research Article
Pages 19-33
Ferid Murad

Regulation of Cytosolic Guanylyl Cyclase by Porphyrins and Metalloporphyrins Original Research Article
Pages 35-65
Louis J. Ignarro

Regulation of Particulate Guonylate Cyclase by Notriuretic Peptides and Escherichia coli Heat-Stable Enterotoxin Original Research Article
Pages 67-86
Dale C. Leitman, Scott A. Waldman, Ferid Murad

Cyclic GMP and Regulation of Cyclic Nucleotide Hydrolysis Original Research Article
Pages 87-114
William K. Sonnenburg, Joseph A. Beavo

Progress in Understanding the Mechanism and Function of Cyclic GhAP-Dependent Protein Kinase Original Research Article
Pages 115-170
Sharron H. Francis, Jackie D. Corbin

Effects of Cyclic GMP on Smooth Muscle Relaxation Original Research Article
Pages 171-194
Timothy D. Warner, Jane A. Mitchell, Hong Sheng, Ferid Murad

Interrelationships of Cyclic GMP, Inositol Phosphates, and Calcium Original Research Article
Pages 195-216
Masato Hirata, Ferid Murad

Cyclic GMP Regulation of Calcium Slow Channels in Cardiac Muscle and Vascular Smooth Muscle Cells Original Research Article
Pages 217-252
Nicholas Sperelakis, Noritsugu Tohse, Yusuke Ohya, Hiroshi Masuda

Effect of Cyclic GMP on Intestinal Transport Original Research Article
Pages 253-283
Arie B. Vaandrager, Hugo R.De Jonge

Cyclic GMP in Lower Forms Original Research Article
Pages 285-303
Joachim E. Schultz, Susanne Klumpp

Clinical Relationships of Cyclic GMP Original Research Article
Pages 305-319
Jean R. Cusson, Johanne Tremblay, Pierre Larochelle, Ernesto L. Schiffrin, Jolanta Gutkowska, Pavel Hamet

Future Directions Original Research Article
Pages 321-324
Ferid Murad

Index
Pages 325-330

Contents of Previous Volumes
Pages 331-335