Chirality in Drug Design and Development

Indra K. Reddy, Reza Mehvar0-8247-5062-4, 9780824750626

Contributors from universities and drug companies around the world examine a number of topics relating to the development of drug products that are either right-handed or left-handed, rather than the mixture found in natural substances. They discuss crystal structure and physical properties in chiral drugs, the interaction of chiral drugs with chiral excipients in formulation, pharmaceutical considerations in transdermal delivery, stereoselective drug delivery through a prodrug approach, pharmacokinetics and dynamics, regulatory issues of chiral drugs with regard to product development, and recent developments such as using nonconventional ratios of isomers.