Handbook of Platelet Physiology and Pharmacology

Gundu H.R. Rao9780792385387, 0792385381

Handbook of Platelet Physiology and Pharmacology represents the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology and function. This edited volume provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs. The book presents an excellent overview of biochemistry, receptor biology, signaling mechanisms, calcium homeostasis, molecular pathology, and comparative physiology of platelets, as well as the pharmacology of antiplatelet drugs and clinical trials. Handbook of Platelet Physiology and Pharmacology will prove a useful reference for hematologists, cell biologists, biochemists, pathologists, and other researchers in the areas of cell biology, pathobiology, atherosclerosis, thrombosis, and biomedical engineering.

---

Table of contents :
Titul……Page 1
List of Contributors……Page 3
PREFACE……Page 6
Contents……Page 8
1. Platelet Physiology and Pharmacology: An Overview……Page 20
2. Human Platelet Thrombin Receptors and the Two Receptor Model for Platelet Activation……Page 40
3. Platelet Thromboxane Receptors: Biology and Function……Page 57
4. Collagen Receptors: Biology and Functions……Page 99
5. Adenosine Receptors: Biology and Function……Page 121
6. Platelet Activating Factor and Platelets……Page 139
7. Platelet Glycoprotein Ib-V-IX: Biology and Function……Page 161
8. Fibrinogen Receptors: Biology and Function……Page 181
9. Biochemistry of Platelet Activation……Page 207
10. GTP Binding Proteins in Platelets……Page 257
11. Platelet Cyclic Nucleotide Phosphodiesterases……Page 270
12. Polyenoic Fatty Acids and Platelet Function……Page 287
13. Phospholipase A2 in Platelets……Page 312
14. Platelet Biorheology: Adhesive Interactions in Flow……Page 334
15. Platelet Vessel Wall Interactions……Page 361
16. Platelet-Biomaterial Interactions……Page 381
17. Comparative Physiology of Platelets from Different Species……Page 398
18. The Molecular Pathology of Glanzmann’s Thrombasthenia……Page 413
19. Congenital Disorders of Platelet Signal Transduction and Secretion……Page 443
20. Biochemistry of Altered Platelet Reactivity in Hypertension……Page 458
21. Nitric Oxide-Mediated Regulation of Platelet Function……Page 477
22. Aspirin, Prostaglandins and Platelet Function: Pharmacology and Thrombosis Prevention……Page 497
23. Current Developments in Anticoagulant and Antithrombotic Agents……Page 514
24. Randomized Trials of Antiplatelet Therapy……Page 545
Index……Page 568