Molecular Biology in Medicinal Chemistry

D. Steinhilber3-527-29988-2, 3-527-29989-0

Explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. Appropriate for pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action. Content: Cellular assays in drug discovery — Gene knockout models — Reporter gene assay systems for the investigation of GPCRs — From the human genome to new drugs: The potential of orphan GPCRs — Stereoselective synthesis with the help of recombinant enzymes — Nucleic acid drugs — Recent trends in enantioseparation of chiral drugs — Affinity chromatography — NMR-based drug discovery — 13C- and 15N-Isotopic labeling of proteins — Antibody fragments as crystallization enhancers — Pharmacogenetics: the effect of inherited henetic variation on drug disposition and drug response — Pharmacogenomics of bioavailability and elimination — Toxicogenomics: integration of new molecular biological tools in toxicology. Abstract: Explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. Appropriate for pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action