Molecular and Cellular Biology of Neuroprotection in the CNS

Thomas Gillessen, Samantha L. Budd, Stuart A. Lipton (auth.), Christian Alzheimer (eds.)9780306474149, 9780585440347, 030647414X

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

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Table of contents :
Front Matter….Pages i-xvii
Front Matter….Pages 1-1
Excitatory Amino Acid Neurotoxicity….Pages 3-40
Neuronal Survival and Cell Death Signaling Pathways….Pages 41-86
Detrimental and Beneficial Effects of Injury-Induced Inflammation and Cytokine Expression in the Nervous System….Pages 87-113
Cellular and Molecular Determinants of Glial Scar Formation….Pages 115-158
Front Matter….Pages 159-159
Na + Channels and Ca 2+ Channels of the Cell Membrane as Targets of Neuroprotective Substances….Pages 161-181
Intracellular Ca 2+ Handling….Pages 183-196
Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands….Pages 197-223
A Role for Glutamate Transporters in Neurodegenerative Diseases….Pages 225-248
Purines and Neuroprotection….Pages 249-280
Heat Shock Proteins and Neuroprotection….Pages 281-299
Front Matter….Pages 301-301
Neurotrophins….Pages 303-334
Fibroblast Growth Factors and Neuroprotection….Pages 335-351
TGF-ßS and Their Roles in the Regulation of Neuron Survival….Pages 353-374
Vascular Endothelial Growth Factor….Pages 375-394
Front Matter….Pages 395-395
Blood-Brain Barrier Drug Targeting Enables Neuroprotection in Brain Ischemia Following Delayed Intravenous Administration of Neurotrophins….Pages 397-430
Invasive Drug Delivery….Pages 431-451
Front Matter….Pages 453-453
Ischemia and Stroke….Pages 455-473
Neuroprotective Strategies in Alzheimer’s Disease….Pages 475-496
Back Matter….Pages 497-501