Principles of Neural Science

Eric Kandel, James Schwartz, Thomas Jessell9780838577011, 0838577016

Now in resplendent color, the new edition continues to define the latest in the scientific understanding of the brain, the nervous system, and human behavior. Each chapter is thoroughly revised and includes the impact of molecular biology in the mechanisms underlying developmental processes and in the pathogenesis of disease. Important features to this edition include a new chapter – Genes and Behavior; a complete updating of development of the nervous system; the genetic basis of neurological and psychiatric disease; cognitive neuroscience of perception, planning, action, motivation and memory; ion channel mechanisms; and much more.

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Table of contents :
Contents……Page 1
Front Matter……Page 5
1 The Brain and Behavior……Page 15
2 Nerve Cells and Behavior……Page 27
3 Genes and Behavior……Page 40
I The Neurobilogy of Behavior……Page 63
4 The Cytology of Neurons……Page 66
5 Synthesis and Trafficking of Neuronal Protein……Page 86
6 Ion Channels……Page 105
7 Membrane Potential……Page 123
8 Local Signaling: Passive Electrical Properties of the Neuron……Page 136
9 Propagated Signaling: The Action Potential……Page 144
II Cell and Molecular Biology of the Neuron……Page 162
10 Overview of Synaptic Transmission……Page 164
11 Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission……Page 173
12 Synaptic Integration……Page 191
13 Modulation of Synaptic Transmission: Second Messengers……Page 209
14 Transmitter Release……Page 230
15 Neurotransmitters……Page 252
16 Diseases of Chemical Transmission at the Nerve-Muscle Synapse: Myasthenia Gravis……Page 266
III Elementary Interactions Between Neurons: Synaptic Transmission……Page 276
17 The Anatomical Organization of the Central Nervous System……Page 279
18 The Functional Organization of Perception and Movement……Page 295
19 Integration of Sensory and Motor Function: The Association Areas of the Cerebral Cortex and the Cognitive Capabilities of the Brain……Page 304
20 From Nerve Cells to Cognition: The Internal Cellular Representation Required for Perception and Action……Page 331
IV The Neural Basis of Cognition……Page 351
21 Coding of Sensory Information……Page 354
22 The Bodily Senses……Page 369
23 Touch……Page 386
24 The Perception of Pain……Page 404
25 Constructing the Visual Image……Page 420
26 Visual Processing by the Retina……Page 436
27 Central Visual Pathways……Page 448
28 Perception of Motion, Depth, and Form……Page 469
29 Color Vision……Page 489
30 Hearing……Page 504
31 Sensory Transduction in the Ear……Page 524
32 Smell and Taste: The Chemical Senses……Page 538
V Preception……Page 558
33 The Organization of Movement……Page 560
34 The Motor Unit and Muscle Action……Page 581
35 Diseases of the Motor Unit……Page 600
36 Spinal Reflexes……Page 615
37 Locomotion……Page 631
38 Voluntary Movement……Page 647
39 The Control of Gaze……Page 668
40 The Vestibular System……Page 684
41 Posture……Page 697
42 The Cerebellum……Page 711
43 The Basal Ganglia……Page 730
VI Movement……Page 743
44 Brain Stem, Reflexive Behavior, and the Cranial Nerves……Page 745
45 Brain Stem Modulation of Sensation, Movement, and Consciousness……Page 757
46 Seizures and Epilepsy……Page 774
47 Sleep and Dreaming……Page 792
48 Disorders of Sleep and Wakefulness……Page 801
49 The Autonomic Nervous System and the Hypothalamus……Page 809
50 Emotional States and Feelings……Page 825
51 Motivational and Addictive States……Page 838
VII Arousal, Emotion, and Behavioral Homeostasis……Page 854
52 The Induction and Patterning of the Nervous System……Page 856
53 The Generation and Survival of Nerve Cells……Page 874
54 The Guidance of Axons to Their Targets……Page 893
55 The Formation and Regeneration of Synapses……Page 912
56 Sensory Experience and the Fine-Tuning of Synaptic Connections……Page 934
57 Sexual Differentiation of the Nervous System……Page 947
58 Aging of the Brain and Dementia of the Alzheimer Type……Page 961
VIII The Development of the Nervous System……Page 978
59 Language and the Aphasias……Page 981
60 Disorders of Thought and Volition: Schizophrenia……Page 995
61 Disorders of Mood: Depression, Mania, and Anxiety Disorders……Page 1013
62 Learning and Memory……Page 1027
63 Cellular Mechanisms of Learning and the Biological Basis of Individuality……Page 1042
IX Language, Thought, Mood, Learning, and Memory……Page 1068
Appendix A Current Flow in Neurons……Page 1070
Appendix B Ventricular Organization of Cerebrospinal Fluid: Blood-Brain Barrier, Brain Edema, and Hydrocephalus……Page 1077
Appendix C Circulation of the Brain……Page 1086
Appendix D Consciousness and the Neurobiology of the Twenty-First Century……Page 1095
Index……Page 1097