Pharmacotherapy. A Pathophysiologic Approach

Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey9780071416139, 0-07-141613-7

The gold standard text for the therapeutics course mandatory in pharmacy schools. Now in its sixth edition, this classic text continues its long-standing tradition of offering unparalleled guidance in the development of pharmaceutical care plans. The book provides a unique process of thinking about pharmacotherapy the process which uses evidence-based approaches to the drug treatment of diseases.
Features: *FREE Online Resource Center for professors and students – study materials, web chapters, questions and answers, and updates *NEW Key Concepts begin each chapter *Excellent use of algorithms, tables, and charts – provides clear recommendations *“Clinical Controversies” in the treatment sections of disease-oriented chapters

---

Table of contents :
Foreword……Page 15
Foreword to the First Edition……Page 17
Preface……Page 19
Contributors……Page 21
Guiding Principles of Pharmacotherapy……Page 33
1. Pharmacoeconomics: Principles, Methods, and Applications……Page 37
2. Health Outcomes and Quality of Life……Page 53
3. Evidence-Based Medicine……Page 63
4. Documentation of Pharmacy Services……Page 75
5. Clinical Pharmacokinetics and Pharmacodynamics……Page 87
6. Pharmacogenetics……Page 111
7. Pediatrics……Page 127
8. Geriatrics……Page 139
9. Pharmacoepidemiology……Page 151
10. Clinical Toxicology……Page 161
11. Cardiovascular Testing……Page 185
12. Cardiopulmonary Resuscitation……Page 207
13. Hypertension……Page 221
14. Heart Failure……Page 255
15. Ischemic Heart Disease……Page 297
16. Acute Coronary Syndromes……Page 327
17. Arrhythmias……Page 357
18. Diastolic Heart Failure and the Cardiomyopathies……Page 393
19. Venous Thromboembolism……Page 409
20. Stroke……Page 451
21. Hyperlipidemia……Page 465
22. Peripheral Arterial Disease……Page 489
23. Use of Vasopressors and Inotropes in the Pharmacotherapy of Shock……Page 497
24. Hypovolemic Shock……Page 515
25. Introduction to Pulmonary Function Testing……Page 531
26. Asthma……Page 539
27. Chronic Obstructive Pulmonary Disease……Page 573
28. Acute Respiratory Distress Syndrome……Page 593
29. Drug-Induced Pulmonary Diseases……Page 613
30. Cystic Fibrosis……Page 627
31. Evaluation of the Gastrointestinal Tract……Page 641
32. Gastroesophageal Reflux Disease……Page 649
33. Peptic Ulcer Disease……Page 665
34. Inflammatory Bowel Disease……Page 685
35. Nausea and Vomiting……Page 701
36. Diarrhea, Constipation, and Irritable Bowel Syndrome……Page 713
37. Portal Hypertension and Cirrhosis……Page 729
38. Drug-Induced Liver Disease……Page 749
39. Pancreatitis……Page 757
40. Viral Hepatitis……Page 773
41. Quantification of Renal Function……Page 797
42. Acute Renal Failure……Page 817
43. Chronic Kidney Disease: Progression-Modifying Therapies……Page 835
44. Chronic Kidney Disease: Therapeutic Complications……Page 857
45. Hemodialysis and Peritoneal Dialysis……Page 887
46. Drug-Induced Kidney Disease……Page 907
47. Glomerulonephritis……Page 927
48. Drug Therapy Individualization for Patients with Renal Insufficiency……Page 955
49. Disorders of Sodium, Water, Calcium, and Phosphorus Homeostasis……Page 973
50. Disorders of Potassium and Magnesium Homeostasis……Page 1003
51. Acid-Base Disorders……Page 1019
52. Evaluation of Neurologic Illness……Page 1039
53. Multiple Sclerosis……Page 1043
54. Epilepsy……Page 1059
55. Status Epilepticus……Page 1085
56. Acute Management of the Brain Injury Patient……Page 1097
57. Parkinson’s Disease……Page 1111
58. Pain Management……Page 1125
59. Headache Disorders……Page 1141
60. Evaluation of Psychiatric Illness……Page 1159
61. Childhood Disorders……Page 1169
62. Eating Disorders……Page 1183
63. Alzheimer’s Disease……Page 1193
64. Substance-Related Disorders: Overview and Depressants, Stimulants, and Hallucinogens……Page 1211
65. Substance-Related Disorders: Alcohol, Nicotine, and Caffeine……Page 1229
66. Schizophrenia……Page 1245
67. Depressive Disorders……Page 1271
68. Bipolar Disorder……Page 1293
69. Anxiety Disorders I: Generalized Anxiety, Panic, and Social Anxiety Disorders……Page 1321
70. Anxiety Disorders II: Posttraumatic Stress Disorder and Obesessive-Compulsive Disorder……Page 1343
71. Sleep Disorders……Page 1357
72. Diabetes Mellitus……Page 1369
73. Thyroid Disorders……Page 1405
74. Adrenal Gland Disorders……Page 1427
75. Pituitary Gland Disorders……Page 1443
76. Pregnancy and Lactation: Therapeutic Considerations……Page 1461
77. Contraception……Page 1479
78. Menstruation-Related Disorders……Page 1501
79. Endometriosis……Page 1521
80. Hormone Therapy in Women……Page 1529
81. Erectile Dysfunction……Page 1551
82. Management of Benign Prostatic Hyperplasia……Page 1571
83. Urinary Incontinence……Page 1583
84. Function and Evaluation of the Immune System……Page 1601
85. Systemic Lupus Erythematosus and Other Collagen-Vascular Diseases……Page 1617
86. Allergic and Pseudoallergic Drug Reactions……Page 1635
87. Solid-Organ Transplantation……Page 1649
88. Osteoporosis and Osteomalacia……Page 1681
89. Rheumatoid Arthritis……Page 1707
90. Osteoarthritis……Page 1721
91. Gout and Hyperuricemia……Page 1741
92. Glaucoma……Page 1749
93. Allergic Rhinitis……Page 1765
94. Dermatologic Drug Reactions, Cancer……Page 1785
95. Acne Vulgaris……Page 1799
96. Psoriasis……Page 1813
97. Atopic Dermatitis……Page 1829
98. Hematopoiesis……Page 1837
99. Anemias……Page 1849
100. Coagulation Disorders……Page 1877
101. Sickle Cell Disease……Page 1899
102. Drug-Induced Hematologic Disorders……Page 1919
103. Laboratory Tests to Direct Antimicrobial Pharmacotherapy……Page 1935
104. Antimicrobial Regimen Selection……Page 1953
105. Central Nervous System Infections……Page 1967
106. Lower Respiratory Tract Infections……Page 1987
107. Upper Respiratory Tract Infections……Page 2007
108. Skin and Soft Tissue Infections……Page 2021
109. Infective Endocarditis……Page 2041
110. Tuberculosis……Page 2059
111. Gastrointestinal Infections and Enterotoxigenic Poisonings……Page 2079
112. Intraabdominal Infections……Page 2099
113. Parasitic Diseases……Page 2111
114. Urinary Tract Infections and Prostatitis……Page 2125
115. Sexually Transmitted Diseases……Page 2141
116. Bone and Joint Infections……Page 2163
117. Sepsis and Septic Shock……Page 2175
118. Superficial Fungal Infections……Page 2189
119. Invasive Fungal Infections……Page 2205
120. Infections in Immunocompromised Patients……Page 2235
121. Antimicrobial Prophylaxis in Surgery……Page 2261
122. Vaccines, Toxoids, and Other Immunobiologics……Page 2275
123. Human Immunodeficiency Virus Infection……Page 2299
124. Cancer Treatment and Chemotherapy……Page 2323
125. Breast Cancer……Page 2373
126. Lung Cancer……Page 2409
127. Colorectal Cancer……Page 2427
128. Prostate Cancer……Page 2465
129. Lymphomas……Page 2483
130. Ovarian Cancer……Page 2511
131. Acute Leukemias……Page 2529
132. Chronic Leukemias……Page 2557
133. Melanoma……Page 2569
134. Hematopoietic Stem Cell Transplantation……Page 2585
135. Assessment of Nutrition Status and Nutrition Requirements……Page 2603
136. Prevalence and Significance of Malnutrition……Page 2623
137. Parenteral Nutrition……Page 2635
138. Enteral Nutrition……Page 2659
139. Nutritional Considerations in Major Organ Failure……Page 2679
140. Obesity……Page 2703
Glossary……Page 2721
Index……Page 2739