Calcium: A Matter of Life or Death

Joachim Krebs and Marek Michalak (Eds.)9780444528056, 0444528059

Calcium is a versatile carrier of signals regulating many aspects of cellular activity such as fertilization to create a new life and programmed cell death to end it. Calcium homeostasis is strictly controlled by channels, pumps and exchangers functioning as gates for calcium entry and release. Given that calcium is such a versatile messenger the field of calcium signaling is continuously and rapidly expanding. This book reviews the most recent developments in calcium signaling by leading experts in the field. It is a state-of-the-art summary of our present knowledge in this quickly growing field and provides insight into the impressive progress made in many areas of calcium signaling, while reminding us of how much remains to be learned.

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Table of contents :
Content:
Contents
Pages v-xvi

Preface
Page xvii
Joachim Krebs, Marek Michalak

Other volumes in the series
Pages xix-xxi

List of contributors
Pages xxiii-xxvi

The unusual history and unique properties of the calcium signal Review Article
Pages 3-22
Ernesto Carafoli

The evolution of the biochemistry of calcium Review Article
Pages 23-48
Robert J.P. Williams

Calcium-binding proteins and the EF-hand principle Review Article
Pages 51-93
Joachim Krebs, Claus W. Heizmann

Structural aspects of calcium-binding proteins and their interactions with targets Review Article
Pages 95-123
Peter B. Stathopulos, James B. Ames, Mitsuhiko Ikura

Voltage-gated calcium channels, calcium signaling, and channelopathies Review Article
Pages 127-166
Erika S. Piedras-Rentería, Curtis F. Barrett, Yu-Qing Cao, Richard W. Tsien

Exchangers and Ca2+ signaling Review Article
Pages 167-178
Joachim Krebs

The plasma membrane calcium pump Review Article
Pages 179-197
Claudia Ortega, Saida Ortolano, Ernesto Carafoli

Endoplasmic reticulum dynamics and calcium signaling Review Article
Pages 199-218
Allison Kraus, Marek Michalak

Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulum Review Article
Pages 219-228
Chikashi Toyoshima

Ca2+/Mn2+ pumps of the Golgi apparatus and Hailey–Hailey disease Review Article
Pages 229-265
Leonard Dode, Jo Vanoevelen, Ludwig Missiaen, Luc Raeymaekers, Frank Wuytack

IP3 receptors and their role in cell function Review Article
Pages 267-285
Katsuhiko Mikoshiba

Ryanodine receptor structure, function and pathophysiology Review Article
Pages 287-342
Spyros Zissimopoulos, F. Anthony Lai

The calcium/calmodulin-dependent protein kinase cascades Review Article
Pages 345-364
Felice A. Chow, Anthony R. Means

The Ca2+–calcineurin–NFAT signalling pathway Review Article
Pages 365-401
Stefan Feske, Anjana Rao, Patrick G. Hogan

Temporal and spatial regulation of calcium-dependent transcription Review Article
Pages 403-423
Jacob Brenner, Natalia Gomez-Ospina, Ricardo Dolmetsch

Calcium and fertilization Review Article
Pages 425-443
Jong Tai Chun, Luigia Santella

Ca2+ signaling during embryonic cytokinesis in animal systems Review Article
Pages 445-470
Sarah E. Webb, Andrew L. Miller

Mitochondrial Ca2+ and cell death Review Article
Pages 471-481
Tullio Pozzan, Rosario Rizzuto

Calcium signalling, a spatiotemporal phenomenon Review Article
Pages 485-502
Michael John Berridge

Color Plates
Pages 503-549

Index
Pages 551-557